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Review
Bone protective agents in children
  1. Claire Louise Wood1,2,
  2. S Faisal Ahmed3
  1. 1 Division of Developmental Biology, University of Edinburgh Roslin Institute, Roslin, Midlothian, UK
  2. 2 John Walton Muscular Dystrophy Research Centre, Institute of Genetic Medicine, Newcastle upon Tyne, UK
  3. 3 Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK
  1. Correspondence to Professor S Faisal Ahmed, Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Royal Hospital for Children, 1345 Govan Road, Glasgow G51 4TF, UK; faisal.ahmed{at}glasgow.ac.uk

Abstract

Evaluation of bone health in childhood is important to identify children who have inadequate bone mineralisation and who may benefit from interventions to decrease their risk of osteoporosis and subsequent fracture. There are no bone protective agents that are licensed specifically for the prevention and treatment of osteoporosis in children. In this review, we discuss the mechanism of action and use of bisphosphonates and other new and established bone protective agents in children.

  • bone disease
  • therapeutics

https://doi.org/10.1136/archdischild-2016-311820

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    Footnotes

    • Contributors CW wrote the first draft, SFA edited and approved the final version.

    • Funding CW and SFA: Medical Research Council and Muscular Dystrophy UK MR/N020588/1, SFA: Chief Scientist Office CAF/DMD/14/01.

    • Competing interests SFA: diurnal research grant, Novo Nordisk (data monitoring board and educational meetings), Kyowa Kirin (consultancy).

    • Provenance and peer review Commissioned; externally peer reviewed.