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Postprandial hyperinsulinaemic hypoglycaemia and type 1 diabetes mellitus

Abstract

A patient with severe postprandial hyperinsulinaemic hypoglycaemia (PPHH) for 4 years developed type 1 diabetes mellitus. She had no insulin or insulin receptor antibodies but was positive for islet cell and glutamic acid decarboxylase (GAD) antibodies. PPHH prior to the onset of type 1 diabetes mellitus has not been previously described and may be a prodrome of type 1 diabetes mellitus.

  • DM, diabetes mellitus
  • GAD, glutamic acid decarboxylase
  • IAS, insulin autoimmune syndrome
  • OGTT, oral glucose tolerance test
  • PPHH, postprandial hyperinsulinaemic hypoglycaemia

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    BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health