Article Text
PDFAcute paediatrics
Chemokine response in children with SARS
Abstract
The chemokine response of eight children with serologically confirmed severe acute respiratory syndrome (SARS) was longitudinally monitored. All had raised plasma interferon γ inducible protein (IP-10) concentrations, which suggested an active type 1 T-helper lymphocyte mediated immune response. High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients.
- IP-10, interferon γ inducible protein
- MCP-1, monocyte chemoattractant protein 1
- MIG, monokine induced by interferon γ
- RANTES, regulated on activation normal T cell expressed and secreted
- SARS, severe acute respiratory syndrome
- SARS-CoV, SARS coronavirus
- Th1, type 1 T helper
- chemokines
- SARS