Article Text
Acute paediatrics
HBV associated nephrotic syndrome: resolution with oral lamivudine
Abstract
A 6 year old boy presenting with a five month history of fever, lethargy, and anorexia, was found to have hepatitis B associated membranous glomerulonephropathy and nephrotic syndrome. After two months treatment with oral lamivudine, his proteinuria cleared and serum albumin and aminotransferases normalised, associated with disappearance of hepatitis B e antigen (HBeAg) and appearance of anti-HBeAg antibodies. After 12 months, without side effects, lamivudine was discontinued. He remains well 11 months off treatment.
- membranous glomerulonephropathy
- hepatitis B virus
- lamivudine
- HBeAg, HBV e antigen
- HBsAg, HBV surface antigen
- HBV, hepatitis virus B
- HBVMN, hepatitis virus B membranous glomerulonephropathy
- IFN, interferon
- Ig, immunoglobulin