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a Robert Vines
Growth Research Centre, New Children's Hospital, PO Box 3515, Parramatta, NSW 2145, Australia, b Centre for Kidney Research, New Children's Hospital
Correspondence to: Dr Cowell.
Accepted 22 July 1998
OBJECTIVES
Polymorphism of the vitamin D receptor
(VDR), collagen 
I type I (Col I I), and oestrogen receptor (ER)
genes have been shown to account for some of the heritability of bone
mineral density (BMD) in adults. This study examined this relation in prepubertal children.
METHODS AND SUBJECTSThe relation between
genotypes of VDR gene (Taq I, Bsm I, Fok I), Col I I gene (Msc I),
and ER gene (Pvu II) with areal BMD, volumetric BMD, and growth were
examined in 114 (68 girls) healthy 7 year old, white children.
RESULTSThe genotype of the VDR gene (Taq I)
correlated with lumbar spine (L1-4) volumetric BMD in girls only, but
at no other bone sites. In girls, VDR genotype affected areal BMD at
all sites. After adjusting for height and weight, however, this effect
was explained completely by the independent effect of the VDR genotype on growth. Girls with genotype TT, were 3.9 kg heavier and 4.1 cm
taller than those with tt, but this relation was not present at birth.
No relation was found between genotypes of the VDR gene (Fok I), Col I
I gene (Msc I), or ER gene (Pvu II) and BMD or growth variables.
CONCLUSIONSIn prepubertal girls, VDR
alleles contribute to lumbar spine volumetric BMD variance, but the
areal BMD effect reflects the relation between areal BMD and growth.
VDR alleles might affect postnatal growth regulation.
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