| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Department of
Paediatrics, Uppsala University Children's Hospital, S-751 85 Uppsala,
Sweden, b Department of Clinical Genetics, Uppsala
University Children's Hospital, c Department of Paediatrics, General Hospital,
Malmö, Sweden
Correspondence to: Dr Annerén. e-mail: goran.anneren{at}ped.uas.lul.se
Accepted 22 April 1998
BACKGROUND
The
prevalence of thyroid disease is increased in Down's syndrome. Most
available data come from cross sectional studies.
AIMSTo study
longitudinally thyroid function in patients with Down's syndrome in
Uppsala county (85 patients) up to the age of 25 years.
METHODSObservational
study based on yearly follow up in a children's clinic. Thyroid
function tests were performed at each visit to the clinic.
RESULTSHypothyroidism
was found in 30 and hyperthyroidism was found in two of the 85 patients. No sex difference was seen. Half of the patients with
hypothyroidism acquired the condition before the age of 8 years, but
only one of them displayed thyroid autoantibodies at diagnosis. Most
patients who developed hypothyroidism after this age had thyroid
autoantibodies. In the prepubertal patients with hypothyroidism, growth
velocity was lower during the year before the start of thyroxine
treatment than during the year after treatment began; it was also lower
than that of sex and age matched euthyroidic children with Down's syndrome.
CONCLUSIONThyroid
dysfunction in patients with Down's syndrome is common in childhood.
Consequently, annual screening is important. Autoimmune thyroid disease
is uncommon in young children with Down's syndrome but is common after
8 years of age.
This article has been cited by other articles:
|
|
 |
|
  K. N. Carroll, P. G. Arbogast, J. A. Dudley, and W. O. Cooper Increase in Incidence of Medically Treated Thyroid Disease in Children With Down Syndrome After Rerelease of American Academy of Pediatrics Health Supervision Guidelines Pediatrics, August 1, 2008; 122(2): e493 - e498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Gillespie, R. J. Dix, A. J.K. Williams, R. Newton, Z. F. Robinson, P. J. Bingley, E. A.M. Gale, and J. P.H. Shield Islet Autoimmunity in Children With Down's Syndrome Diabetes, November 1, 2006; 55(11): 3185 - 3188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cakan and D. Kamat Commentary Clinical Pediatrics, March 1, 2006; 45(2): 192 - 195. [PDF]
|
|
|
|
 |
|
 P A Gibson, R W Newton, K Selby, D A Price, K Leyland, and G M Addison Longitudinal study of thyroid function in Down's syndrome in the first two decades Arch. Dis. Child., June 1, 2005; 90(6): 574 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Toscano, G Pacileo, G Limongelli, M Verrengia, O Di Mita, S Di Maio, M Salerno, E Del Giudice, B Caniello, R Calabro, et al. Subclinical hypothyroidism and Down's syndrome; studies on myocardial structure and function Arch. Dis. Child., November 1, 2003; 88(11): 1005 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. P. van Trotsenburg, T. Vulsma, H. M. van Santen, W. Cheung, and J. J. M. de Vijlder Lower Neonatal Screening Thyroxine Concentrations in Down Syndrome Newborns J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1512 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W Chemaitilly, C Thalassinos, S Emond, and E Thibaud Metrorrhagia and precocious puberty revealing primary hypothyroidism in a child with Down's syndrome Arch. Dis. Child., April 1, 2003; 88(4): 330 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vaidya, P. Kendall-Taylor, and S. H. S. Pearce The Genetics of Autoimmune Thyroid Disease J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5385 - 5397. [Full Text] [PDF]
|
|
|
|
|
|
M E Styles, T J Cole, J Dennis, and M A Preece New cross sectional stature, weight, and head circumference references for Down's syndrome in the UK and Republic of Ireland Arch. Dis. Child., August 1, 2002; 87(2): 104 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Committee on Genetics Health Supervision for Children With Down Syndrome Pediatrics, February 1, 2001; 107(2): 442 - 449. [Abstract] [Full Text]
|
|
|
|
|
|
S E Noble, K Leyland, C A Findlay, C E Clark, J Redfern, J M Mackenzie, R W A Girdwood, and M D C Donaldson School based screening for hypothyroidism in Down's syndrome by dried blood spot TSH measurement Arch. Dis. Child., January 1, 2000; 82(1): 27 - 31. [Abstract] [Full Text]
|
|
|
|
|
|
E. B POSNER and A. F COLVER Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity Arch. Dis. Child., September 1, 1999; 81(3): 278o - 278. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| ARCH DIS CHILD | FETAL NEONATAL ED | ED PRACTICE |
