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a Department of
Thoracic Medicine, University of Melbourne, Melbourne, Victoria,
Australia, b Department of Paediatrics, University of
Melbourne, c Department of
Clinical Epidemiology and Statistics, Royal Children's Hospital,
Parkville, Melbourne, Victoria 3052, Australia
Correspondence to: Dr A B Chang, Department of Respiratory Medicine, Mater Children's Hospital, South Brisbane, Queensland 4101, Australia.email: achang{at}mater.org.au
Accepted 16 March 1998
AIMS
To test the
hypothesis that inhaled salbutamol or beclomethasone will reduce the
frequency of cough in children with recurrent cough. A secondary aim
was to determine if the presence of airway hyperresponsiveness (AHR)
can predict the response.
DESIGNRandomised,
double blind, placebo controlled trial.
METHODSDuring a
coughing phase, 43 children (age 6-17 years) with recurrent cough were
randomised to receive inhaled salbutamol or placebo (phase I) for 5-7
days and then beclomethasone or placebo (phase II) for 4-5 weeks, and
in a subgroup of children for 8-9 weeks. The children used an
ambulatory cough meter, kept cough diaries, and performed the capsaicin
cough sensitivity, hypertonic saline bronchoprovocation, and skin prick tests.
RESULTSSalbutamol or
beclomethasone had no effect on cough frequency or score, irrespective
of the presence of AHR.
CONCLUSIONSMost
children with recurrent cough without other evidence of airway
obstruction, do not have asthma and neither inhaled salbutamol nor
beclomethasone is beneficial.
This article has been cited by other articles:
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 A. Gupta, M. McKean, and A. B Chang Management of chronic non-specific cough in childhood: an evidence-based review Arch. Dis. Child. Ed. Pract., April 1, 2007; 92(2): 33 - 39. [Full Text] [PDF]
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 A. B. Chang and W. B. Glomb Guidelines for Evaluating Chronic Cough in Pediatrics: ACCP Evidence-Based Clinical Practice Guidelines Chest, January 1, 2006; 129(1_suppl): 260S - 283S. [Abstract] [Full Text] [PDF]
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P. V. Dicpinigaitis and R. V. Alva Safety of Capsaicin Cough Challenge Testing Chest, July 1, 2005; 128(1): 196 - 202. [Abstract] [Full Text] [PDF]
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 A. Devenny, H. Wassall, T. Ninan, M. Omran, S. D. Khan, and G. Russell Respiratory symptoms and atopy in children in Aberdeen: questionnaire studies of a defined school population repeated over 35 years BMJ, August 28, 2004; 329(7464): 489 - 490. [Full Text] [PDF]
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J C de Jongste and M D Shields Cough * 2: Chronic cough in children Thorax, November 1, 2003; 58(11): 998 - 1003. [Abstract] [Full Text] [PDF]
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 A B Chang, P D Phelan, C F Robertson, R G D Roberts, and S M Sawyer Relation between measurements of cough severity Arch. Dis. Child., January 1, 2003; 88(1): 57 - 60. [Abstract] [Full Text] [PDF]
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H. Marcovitch Atoms Arch. Dis. Child., January 1, 2003; 88(1): 1 - 1. [Full Text] [PDF]
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 J V West Acute upper airway infections: Childhood respiratory infections Br. Med. Bull., March 1, 2002; 61(1): 215 - 230. [Abstract] [Full Text] [PDF]
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 P. G. GIBSON, J. L. SIMPSON, A. C. CHALMERS, R. C. TONEGUZZI, P. A. B. WARK, A. J. WILSON, and M. J. HENSLEY Airway Eosinophilia Is Associated with Wheeze But Is Uncommon in Children with Persistent Cough and Frequent Chest Colds Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 977 - 981. [Abstract] [Full Text] [PDF]
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 J. Y Paton A 14-day regimen of high-dose inhaled corticosteroids was more effective than placebo for persistent nocturnal cough Evid. Based Med., January 1, 2000; 5(1): 19 - 19. [Full Text] [PDF]
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D. J Keeley and M. Silverman Issues at the interface between primary and secondary care in the management of common respiratory disease bullet 2: Are we too ready to diagnose asthma in children? Thorax, July 1, 1999; 54(7): 625 - 628. [Full Text]
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M J Davies, P Fuller, A Picciotto, and S A McKenzie Persistent nocturnal cough: randomised controlled trial of high dose inhaled corticosteroid Arch. Dis. Child., July 1, 1999; 81(1): 38 - 44. [Abstract] [Full Text]
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A. B CHANG Isolated cough: probably not asthma Arch. Dis. Child., March 1, 1999; 80(3): 211 - 213. [Full Text]
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J. M Rothenberg, A B Chang, I B Masters, H A Thiadens, and D S Postma Identifying asthma and chronic obstructive pulmonary disease in patients with persistent cough BMJ, October 17, 1998; 317(7165): 1078a - 1078. [Full Text]
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