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a Southampton General Hospital, Southampton:
MRC Environmental Epidemiology Unit, b Department of Microbiology, Public Health
Laboratory Service, c Department of
Medicine, d Queen Alexandra's Hospital,
Portsmouth: Department of Gastroenterology
Correspondence to: Dr Caroline Fall, Epidemiologist, MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD.
Accepted 23 June 1997
AIM
To examine childhood correlates of
Helicobacter pylori infection in adults.
DESIGNFollow up study of men and women whose
birth weight, weight at age 1 year, and feeding in infancy were
recorded by health visitors. Data on childhood housing conditions were
obtained by recall.
SUBJECTS631 men and 389 women born in
Hertfordshire during 1920-30 and still living in the east or northwest
districts of the county.
MAIN OUTCOME MEASURESSerum H pylori
IgG antibodies measured by enzyme linked immunosorbent assay.
RESULTSIndependent of their current social class,
subjects were more likely to be H pylori seropositive if
they had large numbers of siblings (p < 0.0001), and if they had lived
in a crowded house (p = 0.001), or shared a bedroom or bed in childhood
(p = 0.02). Low weight at 1 year was associated with increased
seropositivity rates in men (p = 0.0002), but not women (p = 0.8). Men
and women who were breast fed in infancy were less likely to be
seropositive than those who were bottle fed (p = 0.08).
CONCLUSIONSThe findings support the
current view that H pylori infection is often acquired in
childhood by close person to person contact, and persists into adult
life. H pylori infection may be a cause of failure to
thrive in infancy, especially in boys. Alternatively, small infants may
be more susceptible to infection. Breast feeding may prevent early infection.
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