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Arch Dis Child 1997;77:223-226 ( September )

Hepatitis GB virus-C/hepatitis G virus infection in liver disease

Ikuo Nagata,a Nikos Tzampouras,b Shilpa Chokshi,b Nikolai V Naoumov,b Paul Cheeseman,c Heather M Smith,d Alastair J Baker,c Roger Williams,b Giorgina Mieli-Verganie

a Department of Child Health, King's College School of Medicine and Dentistry and Institute of Hepatology University College London Medical School, London, b Institute of Hepatology University College London Medical School, London, c King's College Hospital, London: Department of Child Health, d Institute of Liver Studies, e Department of Child Health, King's College School of Medicine and Dentistry, London

Correspondence to: and reprint requests to: Dr Alastair J Baker, Department of Child Health, King's College Hospital, Denmark Hill, London SE5 9RS.


Accepted 27 June 1997

Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dysfunction after liver transplantation associated with autoimmune features, 20 with cryptogenic liver disease, and 29 with autoimmune liver disease. HGV RNA detected by reverse transcription polymerase chain reaction was found to be positive in 4/106 patients (3.8%). Risk factors were identified in three patients, including blood transfusion and/or medical treatment in Eastern Europe. The prevalence was higher than that of blood donors but lower than that of 2 adult patients with liver disease. HGV is not associated with any specific disease group and does not seem to be a major aetiological agent of liver disease in childhood in the UK.

Keywords: hepatitis G virus; routes of infection; epidemiology

© 1997 by Archives of Disease in Childhood


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Outcome of mother to infant acquired GBV-C/HGV infection
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1999; 80(1): 72F - 73.
[Abstract] [Full Text]


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