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Kinderpoliklinik, Klinikum Innenstadt
der Ludwig-Maximilians- Universität, Pettenkoferstrasse 8a,
D-80336 Munich, Germany
Correspondence to: Professor Koletzko.
Accepted 9
April 1997
A case is reported of a 14 month old boy with severe dietary
vitamin B-12 deficiency caused by his mother's vegan diet. Cinical, electroencephalography (EEG), and haematological findings are described. Cranial magnetic resonance imaging (MRI) showed severe frontal and frontoparietal cranial atrophy. Vitamin B-12 supplements led to a rapid improvement of haematological and neurological symptoms.
Serum vitamin B-12 and urinary methylmalonate excretion were normal 10 days after treatment began. After six weeks, EEG was normal and cranial
MRI after 10 weeks showed complete disappearance of all structural
abnormalities. Cognitive and language development, however, remained
seriously retarded at the age of 2 years. It is concluded that
infantile vitamin B-12 deficiency induced by maternal vegan diets may
cause lasting neurodisability even though vitamin B-12 supplementation
leads to rapid resolution of cerebral atrophy and
electroencephalographic abnormality.
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