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a Department of Paediatrics,
Länssjukhuset Ryhov, Jönköping, Sweden, b Department of Paediatrics, University Hospital, Linköping,
Sweden, c Department of Paediatrics, Länssjukhuset, Kalmar, Sweden, d Mead Johnson Nutritional Group,
Evansville, Indiana, USA
Correspondence to: Dr Göran Oldæus, Department of Paediatrics, Länssjukhuset Ryhov, S-551 85 Jönköping, Sweden.
Accepted 17 March 1997
The allergy preventive effect of extensively (N) and partially
(PH) hydrolysed cows' milk formulas compared with a regular formula
(RM) was assessed in 155 infants with a family history of allergy. No
cows' milk was given during the first nine months of life and no egg
and fish up to 12 months of age. Breast feeding mothers avoided the
same foods. At weaning the infants were randomised to one of the
formula groups. The cumulative incidence of atopic symptoms at 18 months was 51, 64, and 84% in the N, PH, and RM groups, respectively.
From 6 to 18 months there were significantly less cumulative atopic
symptoms in the N group compared with the RM group, and significantly
less than the PH group up to 6 (N = 25%; PH = 46%) and 9 months (N = 34%, PH = 58%). At 9 months significantly fewer infants in the N
group (10%) than in the PH group (33%) had a positive skin prick test
to eggs. The findings support an allergy preventive effect of an
extensively hydrolysed formula, but not of a partially hydrolysed
formula, during the first 18 months of life of high risk infants.
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