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a Neurology
Service, Department of Paediatrics, Hôpital de Bicêtre, Le
Kremlin-Bicêtre Cedex, France, b Intensive Care Unit,
Hôpital de Bicêtre, Le Kremlin-Bicêtre Cedex, France, c INSERM U 292 Epidemiology Service, Hôpital de
Bicêtre, Le Kremlin-Bicêtre Cedex, France
Correspondence to: Dr Guillaume Sébire, Service de Neurologie, Département de Pédiatrie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275, Le Kremlin-Bicêtre Cedex, France.
Accepted 26 October 1996
No effective treatment has been shown for patients with acute
transverse myelopathy. In an open study five children with severe acute
transverse myelopathy were treated with intravenous methylprednisolone and compared with a historical group of 10 patients. The results show
that in the methylprednisolone treatment group compared with the
historical group of 10 patients: the median time to walk independently was significantly reduced (23 v 97 days); the proportion
of patients with a full recovery within 12 months was significantly
higher (80 v 10%); all patients had complete motor
recovery within one year in contrast with only two of 10 patients in
the historical group; and serious adverse effects did not occur. This
pilot study suggests that high dose methylprednisolone is effective in
the treatment of acute transverse myelopathy.
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