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a Department of Paediatrics, Poole NHS Trust Hospital,
Dorset, b Medical Statistics and Computing, Southampton General Hospital
Correspondence to: Dr C W Godden, Paediatric Department, Children's Unit, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey GU2 5XX.
Accepted 28 August 1996
AIMS
To determine whether nebulised budesonide
improves the symptoms or shortens the duration of stay of children
admitted to hospital with a clinical diagnosis of croup.
METHODSA prospective, randomised, double blind
placebo controlled trial. Patients received either nebulised budesonide
or placebo every 12 hours. The main outcome measures were duration of
inpatient stay and croup scores at 30 minutes, one, two, four, 12, and
24 hours.
RESULTS87 patients (89 admissions) aged 7-116
months entered the trial. Nebulised budesonide was associated with a
significant improvement in symptoms at 12 hours (95% confidence
interval (CI) 1 to 3) and 24 hours (95% CI 0 to 3). Patients with an
initial croup score above 3 demonstrated a significant improvement in
symptoms at two hours (95% CI 1 to 3). Nebulised budesonide was also
associated with a 33% reduction in the length of stay (95% CI 2% to
63%) when the confounding variables of age, initial croup score, and coryzal symptoms were taken into consideration.
CONCLUSIONSNebulised budesonide is an effective
treatment for children admitted to hospital with a clinical diagnosis
of croup.
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